ACAN Gene VNTR Polymorphism and Intervertebral Disc Degeneration in a Turkish Population

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Oz T., Kaya I., NURSAL A. F., AYDIN H. E., DEMİR O., YİĞİT S.

HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI, vol.58, no.4, pp.309-314, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.4274/haseki.galenos.2020.6006
  • Journal Name: HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.309-314
  • Keywords: Intervertebral disc degeneration, aggrecan, VNTR, PCR, AGGRECAN GENE, VARIABLE NUMBER, ASSOCIATION
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Aim: Intervertebral disc degeneration (IVDD) is caused by several genetic and environmental factors. Aggrecan is the major component of intervertebral disk matrix proteoglycan with multiple functional domains. The aim of this study was to investigate the possible association between ACAN (coding aggrecan) gene variable number tandem repeat (VNTR) polymorphism and susceptibility to IVDD.