The role of palliative radiotherapy in brain metastases BEYIN METASTAZLARINDA PALYATIF RADYOTERAPININ ROLU

Cakir S., Ozbek N., Elgin Y., Kucukplakci B., Soylu B.

Ondokuz Mayis Universitesi Tip Dergisi, vol.14, no.2, pp.118-124, 1997 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 1997
  • Journal Name: Ondokuz Mayis Universitesi Tip Dergisi
  • Journal Indexes: Scopus
  • Page Numbers: pp.118-124
  • Keywords: Brain metastases, Palliative radiotherapy, Treatment response
  • Ondokuz Mayıs University Affiliated: Yes


In this study, patients with brain metastases who were applied palliative cranial radiotherapy have been analysed for objective and clinic response; correlation between these and factors which effect objective response. Between January 1993-February 1994, 33 patients with brain metastases were treated with palliative cranial radiotherapy and 7 patients were out of this study because of the death before evaluation of response. Dose schedules applied to whole brain were 3 Gyx10 for fifteen patients, and 2 Gyx20 for 11 patients. Clinic response has been evaluated one month alter completion of radiotherapy. Complete, partial and stationary response rates were 58% (15 patients), 23% (6 patients) and 15% (4 patients) respectively. Objective response has been evaluated with computerized tomography at the same time with clinic response. Complete, partial and stationary response rates were 42% (11 patients), 39% (10 patients) and 15% (4 patients) respectively and also in one patient, progression has been established (4%). Though, in 14 patients there was an exact correlation between objective and clinic response, in 7 patients clinic response was better than objective response, and 5 patients had the opposite. When the correlations between primary tumor location, histopathologic diagnosis, diameter of lesion, dose per fraction, boost: and objective response were analyzed, only primer tumor location and histopathologic diagnosis was found significant statistically. Patients with squamous cell lung cancer had higher objective response rates than others.