Fabrication and Investigation of Oxidized-β-Cyclodextrin Nanoparticle as a Novel Class pH Responsive Drug Delivery Vehicle

Bergal A., Andaç M.

JOURNAL OF POLYMERS AND THE ENVIRONMENT, cilt.32, sa.7, ss.2924-2936, 2024 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 7
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s10924-023-03082-8
  • Dergi Adı: JOURNAL OF POLYMERS AND THE ENVIRONMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aerospace Database, Agricultural & Environmental Science Database, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Environment Index, Geobase, Greenfile, Metadex, Pollution Abstracts, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.2924-2936
  • Anahtar Kelimeler: Drug delivery vehicle, Nanocarriers, Oxidized β-Cyclodextrin, pH responsive, Schiff base, β-Cyclodextrin
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Oxidized beta-cyclodextrin (O-beta-CD) nanoparticle was synthesized using oxidation process and Amoxicillin trihydrate (AMOX) model drug was integrated both via Schiff base reaction (C=N bond) as well as inclusion into cavity of O-beta-CD to evaluate pH-responsive drug release behavior. The drug loaded nanocarrier (AM-O-beta-CD) was characterized and results showed this formation, encapsulation and morphological change with average particle size (398 +/- 8.51 nm), negative zeta potential values (- 25.4 +/- 1.54) and high entrapment efficiency (86.1%). The in vitro release behavior of AM-O-beta-CD was evaluated in physiological buffer conditions (0.1 M PBS, pH 5.2, at 37 C-degrees). It was found that drug-loaded AM-O-beta-CD showed sustain, prolonged much higher drug release profile (94.72%) in low pH than that of the pure drug (24.18%) in the same acidic medium. Release kinetics of drug loaded AM-O-beta-CD was determined according to well-known mathematical models, revealing that in vitro release profile could be best expressed by Higuchi kinetic model as release data showed the highest linearity (R-2 = 0.967) so that drug release takes place due to both dissolution and diffusion as it is expected. As a result, it has been proven that the nanostructure has the potential to be pH sensitive drug carrier, especially for drugs containing NH2 side groups in acidic environments.