Fabrication and Investigation of Oxidized-β-Cyclodextrin Nanoparticle as a Novel Class pH Responsive Drug Delivery Vehicle

Bergal A., Andaç M.

JOURNAL OF POLYMERS AND THE ENVIRONMENT, vol.32, no.7, pp.2924-2936, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 7
  • Publication Date: 2024
  • Doi Number: 10.1007/s10924-023-03082-8
  • Journal Name: JOURNAL OF POLYMERS AND THE ENVIRONMENT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aerospace Database, Agricultural & Environmental Science Database, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Environment Index, Geobase, Greenfile, Metadex, Pollution Abstracts, Civil Engineering Abstracts
  • Page Numbers: pp.2924-2936
  • Keywords: Drug delivery vehicle, Nanocarriers, Oxidized β-Cyclodextrin, pH responsive, Schiff base, β-Cyclodextrin
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Oxidized beta-cyclodextrin (O-beta-CD) nanoparticle was synthesized using oxidation process and Amoxicillin trihydrate (AMOX) model drug was integrated both via Schiff base reaction (C=N bond) as well as inclusion into cavity of O-beta-CD to evaluate pH-responsive drug release behavior. The drug loaded nanocarrier (AM-O-beta-CD) was characterized and results showed this formation, encapsulation and morphological change with average particle size (398 +/- 8.51 nm), negative zeta potential values (- 25.4 +/- 1.54) and high entrapment efficiency (86.1%). The in vitro release behavior of AM-O-beta-CD was evaluated in physiological buffer conditions (0.1 M PBS, pH 5.2, at 37 C-degrees). It was found that drug-loaded AM-O-beta-CD showed sustain, prolonged much higher drug release profile (94.72%) in low pH than that of the pure drug (24.18%) in the same acidic medium. Release kinetics of drug loaded AM-O-beta-CD was determined according to well-known mathematical models, revealing that in vitro release profile could be best expressed by Higuchi kinetic model as release data showed the highest linearity (R-2 = 0.967) so that drug release takes place due to both dissolution and diffusion as it is expected. As a result, it has been proven that the nanostructure has the potential to be pH sensitive drug carrier, especially for drugs containing NH2 side groups in acidic environments.