Effects of Intranasal Butorphanol-Diazepam Combination on Ultrasonographic Ocular Biometry, Tear Production, and Intraocular Pressure in Yellow-Legged Gulls<i> (Larus</i> michahellis)


Nacar C., Ersoy B. D., İnal K. S., Nisbet H. Ö.

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, 2025 (SCI-Expanded, Scopus, TRDizin) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2025
  • Doi Numarası: 10.9775/kvfd.2025.35320
  • Dergi Adı: KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The aim of this study was to evaluate the effects of intranasal butorphanol-diazepam sedation on tear production, intraocular pressure (IOP), and ocular biometry in Yellowlegged Gulls (Larus michahellis). Eighteen gulls (nine juvenile, nine adult) undergoing rehabilitation were included. Measurements from the left (n=18) and right (n=18) eyes were analyzed separately for Schirmer Tear Test I (STT-I), IOP, and ultrasonographic parameters. Sedation was achieved with intranasal diazepam (8mg/kg) and butorphanol (1mg/kg). The body weights of the gulls were 670.55 +/- 35.84 g for juveniles and 782.22 +/- 61.61 g for adults. The sedation protocol used in this study produced statistically significant decreases (P<0.05) in juvenile animals in STT-I, anterior chamber depth (ACD), vitreous chamber depth (VCD), axial globe length (AGL), equatorial globe width (EGW) and pecten oculi length (POL). Statistically significant increases (P<0.05) were detected in lens axial height (LAH) and axial globe height (AGH). In adults, statistically significant decreases (P<0.05) were observed in central corneal thickness (CCT), ACD, and VCD while LAH, EGW and AGH showed statistically significant increases (P<0.05). Although decreases in IOP and increases in lens thickness (LT) were noted in both groups, no statistically significant differences were detected. These results indicate that intranasal butorphanol-diazepam provides reliable sedation for ophthalmic assessment in Yellow-legged Gulls without adverse effects; however, its influence on ocular parameters should be considered when interpreting measurements under sedation.