DEFB4A Promoter Polymorphism Is Associated with Chronic Periodontitis: A Case-Control Study

Kurt-Bayrakdar S., Ozturk A., Tekcan E., Kara N.

GENETIC TESTING AND MOLECULAR BIOMARKERS, vol.24, no.3, pp.113-119, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.1089/gtmb.2019.0218
  • Journal Name: GENETIC TESTING AND MOLECULAR BIOMARKERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.113-119
  • Keywords: periodontal disease, genetic susceptibility, multisite variant, promoter, association, GINGIVAL CREVICULAR FLUID, COPY NUMBER VARIATION, ANTIMICROBIAL PEPTIDES, HUMAN BETA-DEFENSIN-2, GENE-EXPRESSION, DEFENSINS, SUSCEPTIBILITY, HEALTH, HBD-1, SNP
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: Human beta-defensin-2 is an antimicrobial weapon peptide with antibiotic properties secreted by the oral cavity to protect the host against microbial attack. The interindividual differences of defensin expression profiles due to genetic variation might be partly responsible for differences in disease susceptibility.