The modulatory effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, vol.128, no.3, pp.724-731, 2022 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 128 Issue: 3
- Publication Date: 2022
- Doi Number: 10.1080/13813455.2020.1722706
- Journal Name: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Page Numbers: pp.724-731
- Ondokuz Mayıs University Affiliated: No
Abstract
Objectives: The main aim of this study was to investigate the effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats. Methods: Irisin was subcutaneously administered with osmotic minipumps at the dose of 100 ng/kg/day for 28 days and then, the serum levels of asprosin, leptin, glucose and lipid profile were investigated. Results: Irisin infusion increased asprosin levels in male rats (p = .02) but not in female rats. Irisin inhibited obesity-induced high glucose, low-density lipoprotein (LDL), triglyceride (TG) and leptin levels in all groups; however, it did not lead to any change in asprosin levels in both obese female and male rats. Conclusions: It was determined that irisin increased serum asprosin levels and decreased LDL, TG, glucose and leptin levels, and this could indicate a protective role of irisin against obesity development.