Mean Platelet Volume and Its Relation With Arterial Stiffness in Patients With Normotensive Polycystic Kidney Disease

ÖRSÇELİK Ö., KOÇYİĞİT İ., AKPEK M., DOĞDU O., Kaya C., ÜNAL A., ...More

JOURNAL OF INVESTIGATIVE MEDICINE, vol.61, no.3, pp.597-603, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.2310/jim.0b013e31828218e7
  • Journal Name: JOURNAL OF INVESTIGATIVE MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.597-603
  • Keywords: mean platelet volume, inflammation, polycystic kidney disease, arterial stiffness, C-REACTIVE PROTEIN, AORTIC STIFFNESS, CARDIOVASCULAR EVENTS, INDEPENDENT PREDICTOR, RHEUMATOID-ARTHRITIS, CORONARY FLOW, ALL-CAUSE, INFLAMMATION, INDEXES, RISK
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: Autosomal-dominant polycystic kidney disease (ADPKD) demonstrates cardiovascular manifestations, such as hypertension, myocardial infarction, and increased carotid intimae-media thickness. These complications are the main cause of morbidity and mortality in patients with ADPKD. Platelet activation and arterial stiffness are important manifestations that independently predict cardiovascular events. In the present study, we aimed to investigate the relation between arterial stiffness, mean platelet volume (MPV), and highly sensitive C-reactive protein (hs-CRP) in patients with normotensive polycystic kidney disease.