Co-trimoxazole-induced toxic epidermal necrolysis treated with high dose methylprednisolone

Soylu H., Akkol N., ERDURAN E., ASLAN Y., Gunes Z., Yıldıran A.

Annals of Medical Sciences, cilt.9, sa.1, ss.38-40, 2000 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 1
  • Basım Tarihi: 2000
  • Dergi Adı: Annals of Medical Sciences
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.38-40
  • Anahtar Kelimeler: Co-trimoxazole, High dose methylprednisolone, Toxic epidermal necrolysis
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Drug reactions are the most common iatrogenic diseases which have many clinical and histopathological subtypes. Toxic epidermal necrolysis (TEN), erythema multiforme, and fixed drug eruptions are dangerous forms of drug reactions which resemble each other clinically. The use of corticosteroids in toxic epidermal necrolysis remains controversial. We reported an 18-month-old girl with TEN who was treated with high-dose methylprednisolone and antibiotherapy. She healed gradually in three weeks' time without complication. In this report, we recommend corticosteroid usage in the treatment of TEN.