Akademik Veri Yönetim Sistemi
The Journal of Neurobehavioral Sciences, cilt.10, sa.2, ss.41-48, 2023 (TRDizin)
TNF (tumor necrosis factor) play crucial role in host
cell defense. TNF-alpha, which is secreted from macrophage has an important role
in proinflammatory response mechanism. TNF-alpha levels increase in autoimmune,
systemic inflammatory diseases, especially rheumatological diseases. Therefore,
TNF-alpha inhibitors are alternant in treatment in many inflammatory diseases.
TNF-alpha inhibitors are not first choice of clinicians due to their important
adverse effects, despite the fact that successful results in diseases
treatments. Treatment with TNF-alpha inhibitors causes different adverse
effects including many bacterial, viral and fungal infectious diseases, lung
diseases, demyelinating diseases and malignancies. One of the most important
adverse effect is tuberculosis by Mycobacterium tuberculosis bacillus.
Tuberculosis occur via reactivation in Latent tuberculosis infection (LTBI). Thus,
tuberculosis screening tests applying before TNF-alpha inhibitors treatment
have an importance. In this review, TNF-alpha inhibitors and their important
adverse effect tuberculosis flaming were discussed and also genetic background
features of these molecules has been explained.