Research Information System
SENDROM, vol.15, no.2, pp.78-86, 2003 (Scopus)
Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. It has been reported that PCOS is an endocrinopathy resulting from insulin resistance and compensatory hyper-insulinemia. This syndrome effect multiple organ systems and may result in serum lipid changes, anovulation, abnormal uterine bleeding, hirsutismus, and infertility. In addition, this syndrome constitue a risk for the development of type 2 diabetes, hypertension, endometrial cancer, and cardiovascular disease. Standart therapy modalities are oral contraceptives, progestins, anti-androgens, and ovulation induction agents. However, insulin-sensitizing agents are now being shown to be useful alone or combined with standart therapies.