Effects of Tacrolimus and Nifedipine, Alone or in Combination, on Gingival Tissues

Pamuk F., Özkan Çetinkaya B., Gülbahar M. Y., Gacar A., Keles G. C., Erisgin Z., ...More

JOURNAL OF PERIODONTOLOGY, vol.84, no.11, pp.1673-1682, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 84 Issue: 11
  • Publication Date: 2013
  • Doi Number: 10.1902/jop.2013.120545
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1673-1682
  • Keywords: Gingival overgrowth, immunohistochemistry, nifedipine, PTEN protein, tacrolimus, RENAL-TRANSPLANT RECIPIENTS, CYCLOSPORINE-A, TUMOR-SUPPRESSOR, NEGATIVE REGULATION, PTEN PHOSPHATASE, OVERGROWTH, EXPRESSION, RATS, HYPERPLASIA, INHIBITION
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: The aim of this study is to compare gingival changes induced by short-and long-term tacrolimus and nifedipine administration, alone or in combination, and evaluate the expression levels of tumor suppressor phosphatase and tensin homolog (PTEN) in drug-induced gingival over-growth.