Effects of Tacrolimus and Nifedipine, Alone or in Combination, on Gingival Tissues

Pamuk, Ferda; Özkan Çetinkaya, Burcu; Gülbahar, Mustafa; Gacar, Ayhan; Keles, Gonca; Erisgin, Zuleyha; Arık, Nurol

doi:10.1902/jop.2013.120545

Effects of Tacrolimus and Nifedipine, Alone or in Combination, on Gingival Tissues

Pamuk F., Özkan Çetinkaya B., Gülbahar M. Y., Gacar A., Keles G. C., Erisgin Z., ...More

JOURNAL OF PERIODONTOLOGY, vol.84, no.11, pp.1673-1682, 2013 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 84 Issue: 11
Publication Date: 2013
Doi Number: 10.1902/jop.2013.120545
Journal Name: JOURNAL OF PERIODONTOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1673-1682
Keywords: Gingival overgrowth, immunohistochemistry, nifedipine, PTEN protein, tacrolimus, RENAL-TRANSPLANT RECIPIENTS, CYCLOSPORINE-A, TUMOR-SUPPRESSOR, NEGATIVE REGULATION, PTEN PHOSPHATASE, OVERGROWTH, EXPRESSION, RATS, HYPERPLASIA, INHIBITION
Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: The aim of this study is to compare gingival changes induced by short-and long-term tacrolimus and nifedipine administration, alone or in combination, and evaluate the expression levels of tumor suppressor phosphatase and tensin homolog (PTEN) in drug-induced gingival over-growth.