Could plasma based therapies still be considered in selected cases with atypical hemolytic uremic syndrome?

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ÖZLÜ S. G., GÜLHAN B., Aydog O., Atayar E., DELİBAŞ A., Parmaksiz G., ...More

TURKISH JOURNAL OF PEDIATRICS, vol.63, no.6, pp.986-993, 2021 (SCI-Expanded, Scopus, TRDizin)

  • Publication Type: Article / Article
  • Volume: 63 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.24953/turkjped.2021.06.006
  • Journal Name: TURKISH JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.986-993
  • Keywords: atypical hemolytic uremic syndrome, treatment, plasma infusion, plasma exchange, outcome, CLINICAL CHARACTERISTICS, COMPLEMENT, MUTATIONS, ECULIZUMAB, MANAGEMENT, IMPACT, MICROANGIOPATHY, AHUS
  • Open Archive Collection: AVESIS Open Access Collection
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background. Atypical hemolytic uremic syndrome (aHUS) occurs due to defective regulation of the alternative complement pathway (ACP) on vascular endothelial cells. Plasma based therapy (PT) was the mainstay of the treatment for aHUS for many years until the introduction of therapies targeting blockage of the complement system. The aim of this study was to evaluate patients with aHUS who had been treated with plasma based therapies alone.