The effects of ascorbic acid on penicillin-induced epileptiform activity in rats
EPILEPSIA, vol.48, no.7, pp.1388-1395, 2007 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 48 Issue: 7
- Publication Date: 2007
- Doi Number: 10.1111/j.1528-1167.2007.01080.x
- Journal Name: EPILEPSIA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1388-1395
- Keywords: epileptiform activity, glutathione, lipid peroxidation, penicillin, vitamin C, LIPID-PEROXIDATION, GLUTATHIONE-PEROXIDASE, OXIDATIVE STRESS, TRACE-ELEMENTS, FREE-RADICALS, IN-VITRO, ETHANOL, ELECTROLYTES, HIPPOCAMPUS, SYSTEMS
- Ondokuz Mayıs University Affiliated: Yes
Abstract
Purpose: Epileptic seizure results from excessive discharge in a population of hyperexcitable neurons. A number of studies help to document the effects of active oxygen free radical scavengers such as alpha-tocopherol or ascorbic acid (vitamin C). In the present study, we examined the effects of ascorbic acid, at the six different doses, on penicillin-induced epileptiform activity.