Interaction Studies of <i>Bis</i>-(<i>p</i>-aminobenzoato)diaquanickel(II) and <i>Bis</i>-(<i>p</i>-aminobenzoato)triaquacadmium(II) Complexes with Cat Genomic DNA

Arslantas A., SÖZMEN M., ERGÜN M. Y.

ASIAN JOURNAL OF CHEMISTRY, no.3, pp.1709-1716, 2010 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Publication Date: 2010
  • Journal Name: ASIAN JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1709-1716
  • Ondokuz Mayıs University Affiliated: No

Abstract

Bis-(p-aminobenzoato)diaquanickel(II) [Ni(p-H(2)N-C(6)H(4)COO)(2)center dot 2H(2)O] and bis-(p-aminobenzoato)triaquacadmium(II) [Cd(p-H(2)N-C(6)H(4)COO)(2)center dot 3H(2)O] complexes derived from p-aminobenzoate are reported. The genomic DNA interactions of these complexes with cat genomic DNA have been investigated with UV spectroscopy, gel electrophoresis and viscosity measurements. Ni(H(2)N-C(6)H(4)COO)(2)center dot 2H(2)O and Cd(H(2)N-C(6)H(4)COO)(2)center dot 3H(2)O complexes exhibit interaction activities with DNA. The experimental results indicate that the complexes can bind to DNA via an intercalative mode. The intrinsic binding constants of the complexes with genomic DNA are 5.2 x 10(5)-2.49 x 10(5) M(-1), respectively.