Upregulation of microRNA-93-5p/microRNA-4668-5p, and promoter methylation of matrix metalloproteinase-3 and interleukin-16 genes in Turkish patients with rheumatoid arthritis

Celik, Zulfinaz; Tural, Şengül; Cengiz, Ahmet; Kara, Nurten; Alaylı, Gamze

doi:10.1016/j.ejr.2020.06.004

Upregulation of microRNA-93-5p/microRNA-4668-5p, and promoter methylation of matrix metalloproteinase-3 and interleukin-16 genes in Turkish patients with rheumatoid arthritis

Celik Z. B., Tural Ş., Cengiz A. K., Kara N., Alaylı G.

EGYPTIAN RHEUMATOLOGIST, cilt.43, sa.1, ss.35-39, 2021 (ESCI, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 43 Sayı: 1
Basım Tarihi: 2021
Doi Numarası: 10.1016/j.ejr.2020.06.004
Dergi Adı: EGYPTIAN RHEUMATOLOGIST
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, Directory of Open Access Journals
Sayfa Sayıları: ss.35-39
Anahtar Kelimeler: Rheumatoid arthritis, MMP-3, IL-16, Methylation, MicroRNA
Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Aim of the work: To investigate promoter methylation of matrix metalloproteinase-3 (MMP-3) and interleukin-16 (IL-16) genes with the expression of miRNA-93-5p and miRNA-4668-5p which target these genes in rheumatoid arthritis (RA), respectively.