Synthesis of 1,2,3-triazole-bound-1,2,4-triazoles containing N-phenylmorpholine structure: antibacterial, antifungal, and antioxidant properties, and AChEinhibition analysis

SANCAK, KEMAL; Aliyeva, Firengiz; Kilinc, Guelsah; Çoruh, Ufuk; Durak, Filiz; Ozsanli, Hanifi; Erturk, Omer

doi:10.24820/ark.5550190.p012.406

Synthesis of 1,2,3-triazole-bound-1,2,4-triazoles containing N-phenylmorpholine structure: antibacterial, antifungal, and antioxidant properties, and AChEinhibition analysis

SANCAK K., Aliyeva F., Kilinc G. G., Çoruh U., Durak F., Ozsanli H., ...More

ARKIVOC, vol.2025, 2025 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 2025
Publication Date: 2025
Doi Number: 10.24820/ark.5550190.p012.406
Journal Name: ARKIVOC
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Directory of Open Access Journals
Ondokuz Mayıs University Affiliated: Yes

Abstract

Azole compounds are the most common antifungals in clinical use; however, their clinical efficacy has been reduced due to drug resistance following prolonged use. Hybrid triazole derivatives with different heterocyclic rings are gaining interest in this field. In this study, different triazole rings are combined by click reaction. In vitro antibacterial, antifungal and antioxidant properties for all compounds were determined. The ability of the compounds to inhibit acetylcholinesterase (AChE) enzyme activity was also investigated.