Synthesis of 1,2,3-triazole-bound-1,2,4-triazoles containing N-phenylmorpholine structure: antibacterial, antifungal, and antioxidant properties, and AChEinhibition analysis

SANCAK, KEMAL; Aliyeva, Firengiz; Kilinc, Guelsah; Çoruh, Ufuk; Durak, Filiz; Ozsanli, Hanifi; Erturk, Omer

doi:10.24820/ark.5550190.p012.406

Synthesis of 1,2,3-triazole-bound-1,2,4-triazoles containing N-phenylmorpholine structure: antibacterial, antifungal, and antioxidant properties, and AChEinhibition analysis

SANCAK K., Aliyeva F., Kilinc G. G., Çoruh U., Durak F., Ozsanli H., ...Daha Fazla

ARKIVOC, cilt.2025, 2025 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 2025
Basım Tarihi: 2025
Doi Numarası: 10.24820/ark.5550190.p012.406
Dergi Adı: ARKIVOC
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Directory of Open Access Journals
Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Azole compounds are the most common antifungals in clinical use; however, their clinical efficacy has been reduced due to drug resistance following prolonged use. Hybrid triazole derivatives with different heterocyclic rings are gaining interest in this field. In this study, different triazole rings are combined by click reaction. In vitro antibacterial, antifungal and antioxidant properties for all compounds were determined. The ability of the compounds to inhibit acetylcholinesterase (AChE) enzyme activity was also investigated.