Electrochemical, Spectroscopic and Computational Studies on Complexation of Oxacillin with Cu(II) and Co(II) ions. Synthesis and Ligand Hydrolysis

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Coskun E., Duman E., AÇAR SELÇUKİ N., Biçer E.

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, cilt.12, sa.10, ss.9364-9377, 2017 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 10
  • Basım Tarihi: 2017
  • Doi Numarası: 10.20964/2017.10.43
  • Dergi Adı: INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.9364-9377
  • Anahtar Kelimeler: Hydrolysis, oxacillin - metal ion complexes, square-wave voltammetry, infrared spectroscopy, density functional theory, BETA-LACTAM ANTIBIOTICS, COPPER(II) COMPLEXES, ANTIBACTERIAL ACTIVITY, ANTIMICROBIAL ACTIVITY, MATRIX COMPONENTS, CRYSTAL-STRUCTURE, AMINO-ACIDS, BY-PRODUCTS, DEGRADATION, OXIDATION
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

In this study, the synthesis and characterization of the complexes of oxacillin with Cu(II) and Co(II) ions are presented. These complexes were characterized by FT-IR spectroscopy and elemental analysis. The complexation process of Cu(II) and Co(II) ions with oxacillin in aqueous medium (Britton-Robinson buffer pH 7.4) was followed by means of square-wave voltammetry. Spectroscopic and elemental analysis results showed that Co(II) and Cu(II) complexes were formed with hydrolysed oxacillin anions. In addition, their stability constants and stoichiometric ratios were determined from voltammetric data. Computational results are in agreement with the experimental findings.