From laboratory studies to clinical applications mesenchymal stem cells in cancer treatment: Translational oncology
Journal of Experimental and Clinical Medicine (Turkey), vol.40, no.1, pp.171-179, 2023 (Scopus)
- Publication Type: Article / Review
- Volume: 40 Issue: 1
- Publication Date: 2023
- Doi Number: 10.52142/omujecm.40.1.32
- Journal Name: Journal of Experimental and Clinical Medicine (Turkey)
- Journal Indexes: Scopus, Academic Search Premier, EMBASE
- Page Numbers: pp.171-179
- Keywords: anti-tumoral activity, cancer, cellular therapy, mesenchymal stem cells
- Open Archive Collection: AVESIS Open Access Collection
- Ondokuz Mayıs University Affiliated: Yes
Abstract
Stem cell-based studies have accelerated to treat various pathologies, particularly neurological, cardiovascular, orthopedic diseases and cancer with the understanding of their therapeutic potential after their discovery. Stem cells have recently aroused great interest as a promising treatment option in fighting to cancer with extensive study in the fields of cancer biology. Nevertheless, much uncertainty regarding the act of stem cells in cancer development and treatment remains obscure before the clinical use of stem cell investigation. Despite many obstacles, the migration ability of stem cells, the bioactive factors they secrete, and their immune regulatory properties make them advantageous for gene therapy strategies. However, unknowns and a lack of scientific data remain concerning the use of stem cell-based therapies. Therefore, more experimental data are needed to confirm the different study results presented by different scientific communities. In this review, we focused on summarizing the available experimental and clinical data on the potential uses of mesenchymal stem cells in cancer therapy.