The histopathological and stereological assessment of the effect of topically administered leptin on cerebral vasospasm in an experimental subarachnoid hemorrhage model

Demirel, Cem; Çokluk, Cengiz; Aksoy, Abdurrahman; Aydin, Kerameddin; Önger, Mehmet; Kuruoglu, Enis; Marangoz, Abdullah; Deniz, Omur; Kaplan, Süleyman

doi:10.3906/sag-1507-110

The histopathological and stereological assessment of the effect of topically administered leptin on cerebral vasospasm in an experimental subarachnoid hemorrhage model

Demirel C., Çokluk C., Aksoy A., Aydin K., Önger M. E., Kuruoglu E., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.47, sa.5, ss.1602-1609, 2017 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 47 Sayı: 5
Basım Tarihi: 2017
Doi Numarası: 10.3906/sag-1507-110
Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.1602-1609
Anahtar Kelimeler: Subarachnoid hemorrhage, cerebral vasospasm, leptin, basilar artery, NITRIC-OXIDE, VASODILATION, OBESITY, HUMANS, GENE, RELATIVES, INSULIN, STROKE, MOUSE, CLUES
Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background/aim: Cerebral vasospasm is a term that refers to prolonged, slowly progressing but reversible pathological narrowing of cerebral arteries occurring several days after subarachnoid hemorrhage (SAH), usually accompanied by a decrease in perfusion distal to the affected artery. Leptin is an endogenous polypeptide hormone that can be carried freely and bound to protein in the blood.