Research Information System
Ondokuz Mayıs Üniversitesi Tıp Dergisi (. Journal of Experimental and Clinical Medicine), vol.41, no.3, pp.491-495, 2024 (Scopus)
Acute cholangitis is a clinical condition that occurs due to stasis and infection of the biliary system, which can recur if left untreated and may lead
to life-threatening consequences. Early diagnosis, severity scoring based on the Tokyo Criteria at the time of diagnosis, and prompt initiation of
treatment can help prevent mortality. This article aims to retrospectively review patients diagnosed with acute cholangitis by observing pus drainage
during Endoscopic Retrograde Cholangiopancreatography (ERCP), determine the diagnostic values and prognostic effects of data obtained from
complete blood counts and evaluate the diagnostic and severity criteria of acute cholangitis, including 331 patients who underwent the procedure
and exhibited pus drainage, along with 300 healthy volunteers. We observed that the most common cause in the etiology of acute cholangitis was
choledocholithiasis. There was a statistically significant difference between the healthy control group and the acute cholangitis group in terms of
leukocyte count (WBC), red cell distribution width (RDW), platelet count (PLT), mean platelet volume/platelet count (MPV/PLT), neutrophil
count/lymphocyte count ratio (NLR), and platelet count/lymphocyte count ratio (PLR) values. ROC analysis revealed that RDW, NLR, and PLR
values had high sensitivity and specificity in distinguishing the acute cholangitis group from the healthy group. When we compared acute cholangitis
severity groups, there was a statistically significant difference between the groups in terms of WBC, RDW, PLT, MPV/PLT, NLR, and PLR values.
Due to the high sensitivity and specificity and easy accessibility of WBC, RDW, PLT, NLR, and PLR tests in diagnosing cholangitis, a closer and
careful evaluation of these tests would be beneficial for early diagnosis and effective treatment of the disease. Additionally, this study confirms the
high accuracy of the Tokyo Criteria in diagnosing acute cholangitis, highlighting the inadequacies of other clinical scoring systems.