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BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, vol.39, no.5, pp.937-953, 2025 (SCI-Expanded)
. Turgenia latifolia is a medicinal plant that has not been studied previously. This study explores the first determination of its chemical profile and biological activities. LC-ESI-MS/MS identified trans-ferulic acid as the main compound in the Et2O extract (10.012 mg/g) and chlorogenic acid in the EtOAc and BuOH extracts (1.944 mg/g and 3.539 mg/g, respectively). All extracts exhibited greater reducing power than the standards. The BuOH extract excelled in DPPH and reducing power (IC50 = 70.09 mu g/mL, A0.5 = 0.83 mu g/mL), while the Et2O extract excelled in o-phenanthroline (A0.5 = 6.34 mu g/mL) and showed the highest UV-B protection (SPF = 35.18). The EtOAc and BuOH extracts surpassed acarbose in alpha-amylase inhibition. The EtOAc extract demonstrated superior inhibition of xanthine oxidase and alpha-glucosidase (IC50 = 195.18 and 432.42 mu g/mL, respectively), while the BuOH extract notably inhibited tyrosinase (IC50 = 360.00 mu g/mL) and showed potent protein denaturation inhibition mu g/mL for MCF-7 and MDA-MB-231, respectively). These findings highlight the pharmacological potential of T. latifolia as a promising source of bioactive compounds for therapeutic applications.