Rice is an important grain crop due to its high domestic consumption and important role in terms of food security globally. Because of the difficulty of crop rotation and fallow-free cultivation in rice production, competitive weed species that have the capacity to reproduce rapidly and are adapted to water have become a problem. The strong negative effects of weeds on rice yield and farm profits have created a demand for cost-effective weed management strategies. As a result of the use of herbicides with the same mode of action for many years, the number and population of weed species resistant to herbicides have increased rapidly. So integrated weed control is the only method and an important solution in managing these weeds that should be developed according to the countries' production systems. Echiochloa crus-galli (Barnyardgrass) is one of the earliest resistant weeds adapted to rice production areas. For effective weed management; it aimed to determine the interaction between the cultivation method, water management and rice varieties (Osmancık, Gönen, Koral). The trials were carried out in Turkiye's Marmara and Black Sea Regions. Experiments were carried out with four replications. The water level (especially the high water level) not only had a highly suppressive effect against weeds but also helped to increase the growth and yield of the rice. The deep and medium water levels increased the rice's tillering number and dry weight. The obtained data revealed that better rice growth and high yield can be achieved by maintaining the water level in rice cultivation areas. The development of competitive and local rice varieties is seen as a viable approach in an integrated herbicide-resistant weed control program.