Association of matrix metalloproteinase-9 promoter gene polymorphism with chronic periodontitis

Keles G. C., Güneş S., Sumer A. P., Sumer M., Kara N., Bagci H., ...More

JOURNAL OF PERIODONTOLOGY, vol.77, no.9, pp.1510-1514, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 77 Issue: 9
  • Publication Date: 2006
  • Doi Number: 10.1902/jop.2006.050378
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1510-1514
  • Keywords: chronic periodontitis, gelatinase, matrix metalloproteinase-9, polymorphism, GINGIVAL CREVICULAR FLUID, LOCALIZED JUVENILE PERIODONTITIS, GELATINASE B-GENE, MATRIX METALLOPROTEINASES, FUNCTIONAL POLYMORPHISM, TISSUE INHIBITORS, JAPANESE PATIENTS, VITAMIN-D, EXPRESSION, DISEASE
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background: Matrix metalloproteinases (MMPs) are related to tissue destruction and remodeling events in periodontal diseases. A single nucleotide polymorphism in the promoter region of human MMP-9 gene is associated with the risk of some inflammatory diseases. Therefore, the aim of this study was to investigate the association between MMP-9 promoter polymorphism and severe generalized chronic periodontitis in a Turkish population.