Association of matrix metalloproteinase-9 promoter gene polymorphism with chronic periodontitis

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Keles G. C., Güneş S., Sumer A. P., Sumer M., Kara N., Bagci H., ...Daha Fazla

JOURNAL OF PERIODONTOLOGY, cilt.77, sa.9, ss.1510-1514, 2006 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 77 Sayı: 9
• Basım Tarihi: 2006
• Doi Numarası: 10.1902/jop.2006.050378
• Dergi Adı: JOURNAL OF PERIODONTOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.1510-1514
• Anahtar Kelimeler: chronic periodontitis, gelatinase, matrix metalloproteinase-9, polymorphism, GINGIVAL CREVICULAR FLUID, LOCALIZED JUVENILE PERIODONTITIS, GELATINASE B-GENE, MATRIX METALLOPROTEINASES, FUNCTIONAL POLYMORPHISM, TISSUE INHIBITORS, JAPANESE PATIENTS, VITAMIN-D, EXPRESSION, DISEASE
• Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background: Matrix metalloproteinases (MMPs) are related to tissue destruction and remodeling events in periodontal diseases. A single nucleotide polymorphism in the promoter region of human MMP-9 gene is associated with the risk of some inflammatory diseases. Therefore, the aim of this study was to investigate the association between MMP-9 promoter polymorphism and severe generalized chronic periodontitis in a Turkish population.