Outcomes of antenatally diagnosed fetal cardiac tumors: a 10-year experience at a single tertiary referral center

Okmen F., Ekici H., HORTU İ., Imamoglu M., Ucar B., Ergenoglu A. M., ...More

Journal of Maternal-Fetal and Neonatal Medicine, vol.35, no.18, pp.3489-3494, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 18
  • Publication Date: 2022
  • Doi Number: 10.1080/14767058.2020.1822316
  • Journal Name: Journal of Maternal-Fetal and Neonatal Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.3489-3494
  • Keywords: Fetal cardiac tumor, fetal rhabdomyoma, prenatal diagnosis, tuberous sclerosis
  • Ondokuz Mayıs University Affiliated: No


Objective: The purpose of this study was to analyze the clinical and perinatal outcomes along with ultrasonographic characteristics of fetuses with a cardiac tumor. Methods: The data were obtained retrospectively between January 2010 and December 2019 in a tertiary referral center. The Cardiovascular Profile Score (CVPS) was used for the diagnosis of heart failure. Clinical outcomes of the cases identified in the postnatal period were analyzed. Results: Fourteen cases were evaluated with the fetal cardiac tumor. One case made the decision to terminate the pregnancy. Perinatal death was seen in 4 (30.7 %) cases out of 13 cases. In 3/14 (21.4%) cases, a solitary cardiac tumor was found while multiple cardiac tumors were found in 11/14 (78.6%) cases. All living cases 9/9 (100%) had the diagnosis of tuberous sclerosis complex (TSC). When the cases which survived were compared with the cases which died during the prenatal period, a significant difference in tumors’ biggest diameters (16.44 ± 5.12 mm vs. 32.25 ± 9.28 mm; p:.011, respectively) was found. No statistically significant difference was found in the number of the tumor(s) and heart failure. Conclusion: Fetal cardiac tumors can have serious perinatal mortality. The cardiac tumor size was found to be associated with perinatal mortality. The survival is not different between the cases with solitary and multiple tumors and those with and without congestive heart failure.