Antipsychotics Induced Reproductive Toxicity by Stimulating Oxidative Stress: A Comparative <i>in Vivo</i> and <i>in Silico</i> Study

DİNCER B., Bulent Yazici A., Cinar I., TOKTAY E., Selli J., ÇADIRCI E., ...More

CHEMISTRY & BIODIVERSITY, vol.20, no.5, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 5
  • Publication Date: 2023
  • Doi Number: 10.1002/cbdv.202201190
  • Journal Name: CHEMISTRY & BIODIVERSITY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: biological activity, medicinal chemistry, toxicology, SEXUAL DYSFUNCTION, POTENTIAL ACETYLCHOLINESTERASE, CARBONIC-ANHYDRASE, TESTICULAR CHANGES, SPERM PARAMETERS, ACCURATE DOCKING, MALE-INFERTILITY, PROLACTIN LEVELS, SCHIZOPHRENIA, ARIPIPRAZOLE
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

The pathophysiological mechanism behind the link between antipsychotic drugs and sexual dysfunction is still unknown. The goal of this research is to compare the potential effects of antipsychotics on the male reproductive system. Fifty rats were randomly assigned into the five groups indicated: Control, Haloperidol, Risperidone, Quetiapine and Aripiprazole. Sperm parameters were significantly impaired in all antipsychotics-treated groups. Haloperidol and Risperidone significantly decreased the level of testosterone. All antipsychotics had significantly reduced inhibin B level. A significant reduction was observed in SOD activity in all antipsychotics-treated groups. While GSH levels diminished, MDA levels were rising in the Haloperidol and Risperidone groups. Also, the GSH level was significantly elevated in the Quetiapine and Aripiprazole groups. By causing oxidative stress and altering hormone levels, Haloperidol and Risperidone are damaging to male reproductivity. This study represents useful starting point for exploring further aspects of the underlying mechanisms reproductive toxicity of antipsychotics.