A Flow-Injection Potentiometric System for Selective and Sensitive Determination of Serum Lithium Level

ÇOLDUR F., Andaç M.

ELECTROANALYSIS, vol.25, no.3, pp.732-740, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1002/elan.201200466
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.732-740
  • Keywords: Lithium determination, Flow injection analysis, Serum analysis, Experimental design, Multivariate optimization, LIQUID MEMBRANE ELECTRODES, 16-CROWN-4 DERIVATIVES, MASS-SPECTROMETRY, BIPOLAR DISORDER, NEUTRAL CARRIERS, BLOOD-SERUM, IONOPHORES, SENSOR, CHROMATOGRAPHY, CATIONS
  • Ondokuz Mayıs University Affiliated: Yes


A potentiometric flow injection system was adopted by using a Li+-selective electrode with improved selectivity for sensitive and selective determination of Li+ in human serum spiked samples. For the optimization of the offered flow injection system, multivariate method was utilized. Potentiometric characteristics of the system were investigated (linear range: 5.0x1051.0x101molL1, slope: 56.93mV per decade, detection limit: 3.4x105molL1, sampling-rate: 40 injections per hour). The detection of Li+ in real serum samples was achieved. The obtained results for the spiked serum samples were in good agreement with IC results at 95% confidence level.