Akademik Veri Yönetim Sistemi
VETERINARSKI ARHIV, cilt.96, sa.1, ss.51-58, 2026 (SCI-Expanded, Scopus)
Hypertrophic cardiomyopathy (HCM) is a common heart disease in cats and can lead to hypoxia, leading to deterioration of cardiac function. In response to hypoxia, the bone marrow increases reticulocyte production to enhance oxygen-carrying capacity. In this study, reticulocyte count (RET), immature reticulocyte fraction (IRF), low fluorescence ratio (LFR), medium fluorescence ratio (MFR), high fluorescence ratio (HFR) values and reticulocyte/lymphocyte (RET/LYM) ratio were evaluated in cats with HCM without anemia. The study group consisted of 30 cats diagnosed with HCM, and the control group consisted of 30 healthy cats. According to the American College of Veterinary Internal Medicine classification manual, cats with left ventricular wall thickness <5 mm were classified as normal, while those with wall thickness >= 6 mm were classified as having HCM. In addition, cats with a left atrium/aorta ratio <1.5 were classified as normal, while cats with a left atrium/aorta ratio >= of 1.6 were classified as having HCM. Physical, radiographic, echocardiographic examination and hematological analysis were performed on the cats in both groups. Following detailed echocardiographic and radiographic examinations, red blood cell, LYM, RET, IRF, LFR, MFR, and HFR values were measured. RET, IRF, MFR, HFR, RET/LYM values were significantly higher in cats with HCM than in healthy controls (P<0.05). LYM and LFR values were significantly lower in cats with HCM than healthy controls (P<0.05). In cats with HCM, non-anemic reticulocytosis due to hypoxia and decreased lymphocyte count due to cardiac dysfunction were observed. In addition, an increased RET/LYM ratio was observed in cats with HCM.