Effects of smoking on the gingival crevicular fluid levels of interleukin-17A, interleukin-17E, and oxidative stress following periodontal treatment process

Lütfioğlu M., Sakallioglu U., Sakallioglu E. E., Otan Özden F., Ürkmez S. S., Bilgici B.

JOURNAL OF PERIODONTAL RESEARCH, vol.56, no.2, pp.388-396, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1111/jre.12831
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.388-396
  • Keywords: IL-17A, IL-17E, periodontal disease, periodontal treatment/therapy, smoking, total anti-oxidant capacity, total oxidative stress, LIPID-PEROXIDATION LEVELS, TOTAL OXIDANT STATUS, SERUM-LEVELS, THERAPY, SALIVA, INFLAMMATION, CYTOKINES, IL-17, CELLS, IL-25
  • Ondokuz Mayıs University Affiliated: Yes


Objective and background: How smoking affects periodontal inflammation and healing still needs to be revealed with all its mechanisms. In this study, the gingival crevicular fluid (GCF) levels of: (a) interleukin-17A (IL-17A) and interleukin-17E(IL-17E) with their ratios and (b) oxidative stress by means of total oxidative stress (TOS), total anti-oxidant capacity (TAOC), and their ratios as the oxidative stress index (OSI) were evaluated and compared for smoking and non-smoking periodontitis patients after a periodontitis management process including both the non-surgical and surgical treatments.