Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia

Erdemli H. K., Yildirimlar P., Alper T. Y., Kocabas R., Salis O., Bedir A.

HYPERTENSION IN PREGNANCY, cilt.33, sa.4, ss.488-497, 2014 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/10641955.2014.946613
  • Dergi Adı: HYPERTENSION IN PREGNANCY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.488-497
  • Anahtar Kelimeler: Heme oxygenase 1, N-myc downstream-regulated gene 1, oxidative stress, preeclampsia, SOLUBLE ENDOGLIN RELEASE, MEAN ARTERIAL-PRESSURE, GROWTH RESTRICTION, EXPRESSION, INDUCTION, PLACENTAS
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objective: To evaluate the utility of serum biomarkers in the diagnosis of preeclampsia (PE) and also investigate possible correlation with pathogenesis of PE. Methods: Maternal serum concentrations of heme oxygenase-1 (HO1) and N-myc downstream-regulated gene 1 (NDRG1) were measured at 27-34 weeks of gestation in a case-control study of 33 pregnant women diagnosed with PE and in 43 normotensive pregnant women without proteinuria. The Mann-Whitney U test and Spearman's correlation were used for statistical analysis. Results: The median serum HO1 level was found to be significantly higher in the PE group [76.7 ng/ml (23.4-445.7)] than control group [55.9 ng/ml (3.7-354.3)] (p = 0.006). Positive correlation was found between HO1 levels with presence of PE (r = 0.316, p = 0.005). There was no significant difference in NDRG1 values between the two groups (p = 0.226). Conclusions: Serum HO1 levels were found to be increased in patients with PE compared with normotensive pregnant women.