Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia

Erdemli H. K., Yildirimlar P., Alper T. Y., Kocabas R., Salis O., Bedir A.

HYPERTENSION IN PREGNANCY, vol.33, no.4, pp.488-497, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.3109/10641955.2014.946613
  • Journal Name: HYPERTENSION IN PREGNANCY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.488-497
  • Keywords: Heme oxygenase 1, N-myc downstream-regulated gene 1, oxidative stress, preeclampsia, SOLUBLE ENDOGLIN RELEASE, MEAN ARTERIAL-PRESSURE, GROWTH RESTRICTION, EXPRESSION, INDUCTION, PLACENTAS
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Objective: To evaluate the utility of serum biomarkers in the diagnosis of preeclampsia (PE) and also investigate possible correlation with pathogenesis of PE. Methods: Maternal serum concentrations of heme oxygenase-1 (HO1) and N-myc downstream-regulated gene 1 (NDRG1) were measured at 27-34 weeks of gestation in a case-control study of 33 pregnant women diagnosed with PE and in 43 normotensive pregnant women without proteinuria. The Mann-Whitney U test and Spearman's correlation were used for statistical analysis. Results: The median serum HO1 level was found to be significantly higher in the PE group [76.7 ng/ml (23.4-445.7)] than control group [55.9 ng/ml (3.7-354.3)] (p = 0.006). Positive correlation was found between HO1 levels with presence of PE (r = 0.316, p = 0.005). There was no significant difference in NDRG1 values between the two groups (p = 0.226). Conclusions: Serum HO1 levels were found to be increased in patients with PE compared with normotensive pregnant women.