Effects of selective serotonin reuptake inhibitors on lidocaine induced convulsions Secici serotonin geri alim inhibitorlerinin lidokaine bagli konvulsiyonlar uzerine etkileri
Ondokuz Mayis Universitesi Tip Dergisi, vol.16, no.2, pp.87-91, 1999 (Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 16 Issue: 2
- Publication Date: 1999
- Journal Name: Ondokuz Mayis Universitesi Tip Dergisi
- Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.87-91
- Keywords: Convulsion, Fluoxetine, Lidocaine, Sertraline
- Ondokuz Mayıs University Affiliated: Yes
Abstract
The aim of this work to investigate the effects of sertraline and fluoxetine on the incidence of lidocaine-induced convulsions in mice. The incidence of lidocaine (70 mg/kg, ip) induced convulsions was decreased (p < 0.05) by acute treatment with sertraline (10 mg/kg, ip) and fluoxetine (20 mg/kg, ip) but not influenced subchronic treatment with both sertraline (5 mg/kg/day, ip) and fluoxetine (10 mg/kg/day, ip). These results suggest that serotonergic system may have an inhibitory effect on lidocaine-induced convulsions and in case of subchronic drug treatment neuroadaptation may occur.