Effects of selective serotonin reuptake inhibitors on lidocaine induced convulsions Secici serotonin geri alim inhibitorlerinin lidokaine bagli konvulsiyonlar uzerine etkileri

Kurt M. S., Çelik S. A.

Ondokuz Mayis Universitesi Tip Dergisi, cilt.16, sa.2, ss.87-91, 1999 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 2
  • Basım Tarihi: 1999
  • Dergi Adı: Ondokuz Mayis Universitesi Tip Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.87-91
  • Anahtar Kelimeler: Convulsion, Fluoxetine, Lidocaine, Sertraline
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The aim of this work to investigate the effects of sertraline and fluoxetine on the incidence of lidocaine-induced convulsions in mice. The incidence of lidocaine (70 mg/kg, ip) induced convulsions was decreased (p < 0.05) by acute treatment with sertraline (10 mg/kg, ip) and fluoxetine (20 mg/kg, ip) but not influenced subchronic treatment with both sertraline (5 mg/kg/day, ip) and fluoxetine (10 mg/kg/day, ip). These results suggest that serotonergic system may have an inhibitory effect on lidocaine-induced convulsions and in case of subchronic drug treatment neuroadaptation may occur.