A hydrazine-bridged dinuclear ruthenium complex: Structural properties and biological activity

ERDENER ÇIRALI D., Dervisoglu G., ÖZDEMİR F. A., ŞERBETÇİ Z., Özdemir N., DAYAN O.

JOURNAL OF MOLECULAR STRUCTURE, vol.1272, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1272
  • Publication Date: 2023
  • Doi Number: 10.1016/j.molstruc.2022.134228
  • Journal Name: JOURNAL OF MOLECULAR STRUCTURE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, INSPEC
  • Keywords: Dinuclear Ru(II) complexes, Hydrazine ligand, Cytotoxicity Antibacterial activity, CRYSTAL-STRUCTURE, CISPLATIN, NMR, MECHANISMS, DIAZENE, STRESS, BAND
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

In this study, a new dimeric Ru(II) complex, [Ru(eta(6)-p-cymene)Cl-2](2) (mu(2)-N-2 H-4) (C1), readily synthesized with a reaction of hydrazine hydrate as ligand and [RuCl2(p-cymene)](2) dimmer in dichloromethane. The C1 complex was characterized structurally using IR, NMR, thermal gravimetry and single-crystal X-ray diffraction and theoretically using DFT techniques. Additionally, electrochemical, and optical properties were investigated in cyclic voltammetry and UV-visible spectroscopy. Furthermore, the C1 complex exhibited great antibacterial activity towards 16 Gram + and Gram - species and cell cytotoxicity towards human SH-SY5Y neuroblastoma cell, DU-145 prostate cancer cell, and A549 lung cancer cell lines. (c) 2022 Elsevier B.V. All rights reserved.