Effects of FSHR Gene Variants on Ovarian Response

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Gulhan C., Özdemir A. Z., Önal M., Tural Ş., Güven D., Koçak İ.

INTERNATIONAL JOURNAL OF HUMAN GENETICS, vol.20, no.1, pp.25-31, 2020 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.31901/24566330.2020/20.01.743
  • Journal Name: INTERNATIONAL JOURNAL OF HUMAN GENETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Agricultural & Environmental Science Database, BIOSIS, EMBASE
  • Page Numbers: pp.25-31
  • Keywords: DNA Sequencing, FSHR Gene, Gene Polymorphism, Infertility, Ovarian Response, STIMULATING-HORMONE RECEPTOR, POLYMORPHISMS, MUTATION, THERAPY, FAILURE
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

The study aimed to evaluate the effects of Follicle Stimulating Hormone Receptor (FSHR) gene rs747317735 and rs6111 variants on ovarian response. The researchers evaluated 57 cases (27of them were poor ovarian responders, 30 cases have normal pregnancy). DNA was isolated from all the cases. The Polymerase Chain Reaction and the next generation DNA sequencing methods were performed for FSHR gene exon 10 analyses. As a result of DNA sequence, the researchers detected a statistically significant difference between patients and control groups for FSHR gene exon 10 rs6166 variant (p=0.033, chi(2) =6.834). The C allele frequency was higher in the patient group (p=0.008, chi(2) =2.897). It was detected that the patients have C allele or CC genotype of FSHR gene rs6166 variant were poor responders for application. It was also found that the frequency of patients have TT genotype was higher in the primary infertile group. These results should be confirmed by other and larger researcher groups.