HLA-B27 polymorphism in Turkish patients with ankylosing spondylitis

Birinci A., Bilgici A., Kuru O., Durupinar B.

RHEUMATOLOGY INTERNATIONAL, cilt.26, sa.4, ss.285-287, 2006 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 4
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1007/s00296-005-0614-x
  • Dergi Adı: RHEUMATOLOGY INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.285-287
  • Anahtar Kelimeler: human leukocyte antigen, HLA-B27, subtypes, B*2705, B*2702, B*2708, SUBTYPES, SUSCEPTIBILITY
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The aim of this study was to determine the distribution of human leukocyte antigen (HLA)-B27 subtypes in serologically HLA-B27-positive ankylosing spondylitis (AS) patients and healthy controls from the Turkish population and to compare this with other reports from other populations. We subtyped HLA-B27 in 38 HLA-B27-positive Turkish patients with AS and 47 HLA-B27-positive healthy controls without AS by polymerase chain reaction with specific sequence primers (PCR-SSP). The results demonstrated that: B*2705 was the predominant subtype among both of the patients (71.1%) and controls (68.0%). B*2702 was observed in 26.3% and 32.0% of the patients and controls, respectively. B*2708 subtype was found in 2.6% of the patients but not among the control group. When the distribution of B27 subtypes in Turkish populations was compared with that in other populations, similar frequencies with the Caucasian-Europe groups were noted. However, this should be interpreted carefully because of the small number of individuals in our study.