Comparison of ProEx C With p16INK4a and Ki-67 Immunohistochemical Staining of Cell Blocks Prepared From Residual Liquid-based Cervicovaginal Material A Pilot Study
CANCER CYTOPATHOLOGY, cilt.114, sa.6, ss.474-480, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 114 Sayı: 6
- Basım Tarihi: 2008
- Doi Numarası: 10.1002/cncr.23951
- Dergi Adı: CANCER CYTOPATHOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.474-480
- Anahtar Kelimeler: ProEx C, p16, Ki-67, cell blocks, liquid-based cervicovaginal cytology, Papanicolaou (Pap) test, high-grade squamous intraepithelial lesion, squamous cell carcinoma, SQUAMOUS INTRAEPITHELIAL LESIONS, MINICHROMOSOME MAINTENANCE PROTEIN-2, TOPOISOMERASE-II-ALPHA, HUMAN-PAPILLOMAVIRUS, IMMUNOCYTOCHEMICAL ASSAY, DNA-REPLICATION, CYTOLOGY, BIOMARKERS, SPECIMENS, MARKERS
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
BACKGROUND. Although liquid-based cervicovaginal cytology has high sensitivity for detecting dysplastic/malignant lesions, many pitfalls exist. Cell blocks call be prepared from residual liquid-based cervicovaginal material and used for immunohistochemistry. The aim of this study was to evaluate a new marker, ProEx C, oil cell blocks and its ability to distinguish dysplastic/malignant lesions from morphologically abnormal but benign cells. The results of this study were compared with previously reported results for p16 and Ki-67 on the same material.