Synthesis, characterization, quantum chemical calculations and antioxidant activity of new bis-isatin carbohydrazone and thiocarbohydrazone derivatives

MUĞLU H., ÇAVUŞ M. S., Bakir T., Yakan H.

JOURNAL OF MOLECULAR STRUCTURE, vol.1196, pp.819-827, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1196
  • Publication Date: 2019
  • Doi Number: 10.1016/j.molstruc.2019.07.002
  • Journal Name: JOURNAL OF MOLECULAR STRUCTURE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.819-827
  • Keywords: Isatin, Carbohydrazide, Antioxidant activity, DFT, QTAIM, Spectroscopic techniques, MANNICH-BASES, SCHIFF, ANTIBACTERIAL, ANTIFUNGAL, ANTICANCER
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

1,5-Bis(5-chloro-2-oxoindolin-3-ylidene)thiocarbohydrazone (3), 1,5-Bis(5-metoxy-2-oxoindolin-3-ylidene)thiocarbohydrazone (4), 1,5-Bis(5-metoxy-2-oxoindolin-3-ylidene)carbohydrazone (5) were obtained from isatins and thio/carbohydrazides under reflux in absolute ethanol. The structures of these synthesized compounds were determined using FT-IR, H-1 NMR, C-13 NMR spectroscopy, and elemental analysis. Quantum chemical calculations were also performed at B3LYP/6-311++G(2d,2p) level in order to obtain information about the molecular geometries and electronic data, such as HOMO-LUMO energy eigenvalues and density of states (DOSs). In addition, structural and antioxidant properties of the compounds were studied theoretically. QTAIM analysis was performed to investigate the relationship between intramolecular interactions, electronic data and antioxidant activity. The in vitro antioxidant activity of all the compounds was determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging method. Antioxidant activity was followed by Ascorbic acid > 3 > 4 > 5. (C) 2019 Elsevier B.V. All rights reserved.