Effects of vitamin D and paricalcitol on epileptogenesis and behavioral properties of WAG/Rij rats with absence epilepsy

Aygun H., Ayyıldız M., Ağar E.

EPILEPSY RESEARCH, vol.157, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 157
  • Publication Date: 2019
  • Doi Number: 10.1016/j.eplepsyres.2019.106208
  • Journal Name: EPILEPSY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Absence epilepsy, Paricalcitol, Vitamin D, Seizure, WAG/Rij rat, DEPRESSIVE-LIKE BEHAVIOR, 1,25-DIHYDROXYVITAMIN-D3 RECEPTOR IMMUNOREACTIVITY, ANTIEPILEPTIC DRUGS, ANIMAL-MODEL, D DEFICIENCY, INDUCED SEIZURES, WAVE DISCHARGES, MICE LACKING, RISK-FACTORS, CHILDREN
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Aim: Vitamin D (Vit D) has been considered as a neurosteroid and has a pivotal role in neuroprotection including epilepsy. Vit D regulator acts via a Vit D receptor (VDR). WAG/Rij rats have a genetically epileptic model of absence epilepsy with comorbidity of depression. The aim of the present study was to investigate the effect of Vit D and paricalcitol (PRC) on WAG/Rij rats.