Metallothionein expression in benign and malignant canine mammary gland tumours


Erginsoy S. D., Sozmen M., Caldin M., Furlanello T.

RESEARCH IN VETERINARY SCIENCE, cilt.81, sa.1, ss.46-50, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 81 Sayı: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.rvsc.2005.09.013
  • Dergi Adı: RESEARCH IN VETERINARY SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.46-50
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

The presence of metallothioneins (MTs) were demonstrated immunohistochemically using a monoclonal antibody (E9) against a conserved epitope of 1 and 11 isoforms in canine mammary tumours. In a semiquantitative analysis MT expression in the tumour cells was observed in 54/54 cases of benign and 32/40 malignant mammary neoplasms. A statistically significant difference at the level of P < 0.01 was observed for MT expression between benign and malign mammary tumours in terms of immunoreactivity score. It is concluded that immunohistochemically demonstrated MT expression is significantly associated with benign canine mammary tumours. (c) 2005 Elsevier Ltd. All rights reserved.