ANTIPROLIFERATIVE EFFECT OF LACTOBACILLUS PLANTARUM L4 STRAIN ISOLATED FROM CERVICOVAGINAL MICROFLORA ON HELA CANCER CELL LINE

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KIRAY E., YALÇIN AZARKAN S., Kariptas E.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, vol.85, no.1, pp.67-76, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 85 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.26650/iuitfd.915299
  • Journal Name: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.67-76
  • Keywords: Lactobacillus plantarum, antiproliferative effect, HeLa, IL-10, TNF-alpha, LACTIC-ACID BACTERIA, HUMAN-PAPILLOMAVIRUS, VAGINAL LACTOBACILLI, PROBIOTIC PROPERTIES, MICROBIOME, MODULATION, SELECTION
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Objective: Lactobacillus has been shown to inhibit proliferation of various cancer cells, but the effects of vaginal Lactobacillus on cervical cancer cells have rarely been reported. The goal of this investigation was to assess the anti-proliferative effect on cancer cell line HeLa (Human Cervical Carcinoma Cell) and potential probiotic properties of Lactobacillus plantarum L4 isolated from cervicovaginal flora of healthy women in Turkey.