ANTIPROLIFERATIVE EFFECT OF LACTOBACILLUS PLANTARUM L4 STRAIN ISOLATED FROM CERVICOVAGINAL MICROFLORA ON HELA CANCER CELL LINE

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KIRAY E., YALÇIN AZARKAN S., Kariptas E.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.85, sa.1, ss.67-76, 2022 (ESCI, Scopus, TRDizin)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 85 Sayı: 1
• Basım Tarihi: 2022
• Doi Numarası: 10.26650/iuitfd.915299
• Dergi Adı: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.67-76
• Anahtar Kelimeler: Lactobacillus plantarum, antiproliferative effect, HeLa, IL-10, TNF-alpha, LACTIC-ACID BACTERIA, HUMAN-PAPILLOMAVIRUS, VAGINAL LACTOBACILLI, PROBIOTIC PROPERTIES, MICROBIOME, MODULATION, SELECTION
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objective: Lactobacillus has been shown to inhibit proliferation of various cancer cells, but the effects of vaginal Lactobacillus on cervical cancer cells have rarely been reported. The goal of this investigation was to assess the anti-proliferative effect on cancer cell line HeLa (Human Cervical Carcinoma Cell) and potential probiotic properties of Lactobacillus plantarum L4 isolated from cervicovaginal flora of healthy women in Turkey.