Does thiol/disulfide homeostasis affect the number of metaphase 2 oocyte in the treatment of in vitro fertilization?

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Özdemir A. Z., Karli P., NEŞELİOĞLU S.

FUTURE SCIENCE OA, vol.6, no.2, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.2144/fsoa-2019-0132
  • Journal Name: FUTURE SCIENCE OA
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Keywords: antioxidants, embryo, in vitro fertilization success, infertility, metaphase 2, oocyte maturation, oxidative stress, pregnancy, serum, thiol, disulfide homeostasis, OXIDATIVE STRESS, MARKER, THIOLS
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Aim: To investigate the effect of thiol/disulfide homeostasis on the number of oocytes retrieved and metaphase 2 (M2) oocytes in patients undergoing in vitro fertilization. Method: A prospective study of 94 patients who were admitted to the in vitro fertilization clinic was conducted. Serum samples were taken on the oocyte pick-up day and kept until the analysis. Thiol and disulfide were measured in order to evaluate the total thiol/disulfide. Results: A statistically significant correlation was observed between disulfide and M2. Conclusion: This study provides an inexpensive and noninvasive method to measure oxidative stress, and suggests that there is a positive correlation between the number of M2 and disulfide, resulting in low-impact oxidative stress.