Two infants with infantile spasms associated with vitamin B12 deficiency

Malbora B., Yuksel D., Aksoy A., Ozkan M.

Pediatric Neurology, cilt.51, sa.1, ss.144-146, 2014 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.pediatrneurol.2014.03.001
  • Dergi Adı: Pediatric Neurology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.144-146
  • Anahtar Kelimeler: infantile spasms, seizure, treatment, vitamin B12 deficiency
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

BACKGROUND: In developing countries, nutritional vitamin B12 deficiency in infants because of maternal deficiency often causes hematological and neurological disorders. However, epilepsy is a rare manifestation of vitamin B12 deficiency. The biological basis for the observed neurological symptoms of infantile vitamin B12 deficiency remains uncertain. There are only a few reports in the English literature regarding the relationship between infantile spasms and vitamin B12 deficiency. PATIENTS: We report two unrelated infants having infantile spasms associated with vitamin B12 deficiency related to maternal nutritional deficiency. RESULTS: During the first month of adrenocorticotropic hormone (ACTH), phenobarbital, and vitamin B12 treatments, both infants' abnormalities resolved. After 3 months, electroencephaography was completely normal. ACTH and phenobarbital treatments were ended. The children are disease-free 9 months after the treatment. CONCLUSIONS: We suggest that vitamin B12 deficiency should be considered in the differential diagnosis of infantile spasms as a treatable cause, especially with a history of maternal nutritional deficiency. © 2014 Elsevier Inc. All rights reserved.