Evaluation of the neurotoxic effects of intrathecal administration of (S)-(+)-Ketoprofen on rat spinal cords: randomized controlled experimental study

Kaya, Cengiz; Atalay, Yunus; Can Meydan, Bilge; Üstün, Yasemin; Köksal, Ersin; Çalışkan, Sultan

doi:10.1016/j.bjan.2019.03.006

Evaluation of the neurotoxic effects of intrathecal administration of (S)-(+)-Ketoprofen on rat spinal cords: randomized controlled experimental study

Kaya C., Atalay Y. O., Can Meydan B., Üstün Y. B., Köksal E., Çalışkan S.

REVISTA BRASILEIRA DE ANESTESIOLOGIA, cilt.69, sa.4, ss.403-412, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 69 Sayı: 4
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.bjan.2019.03.006
Dergi Adı: REVISTA BRASILEIRA DE ANESTESIOLOGIA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.403-412
Anahtar Kelimeler: Cyclooxygenase inhibitor, Intrathecal injection, (S)-(+)-Ketoprofen, Neurotoxicity, Inflammation, POSTOPERATIVE PAIN, DICLOFENAC SODIUM, KETOROLAC, DRUGS, CYCLOOXYGENASE-1, LIDOCAINE, TOXICITY, FENTANYL, SAFETY, ADULT
Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background and objectives: Intrathecal administration of non-steroidal anti-inflammatory drugs is more efficacious for post-operative pain management. Cyclooxygenase inhibiting nonsteroidal anti-inflammatory drugs like (S)-(+)-Ketoprofen, may be effective at lower intrathecal doses than parenteral ones. Preclinical safety regarding possible neurotoxicity associated with the intrathecal (S)-(+)-Ketoprofen was not evaluated. Here we analysed the neurotoxicity of intrathecally administered (S)-(+)-Ketoprofen in rats.