Evaluation of the neurotoxic effects of intrathecal administration of (S)-(+)-Ketoprofen on rat spinal cords: randomized controlled experimental study

Kaya C., Atalay Y. O., Can Meydan B., Üstün Y. B., Köksal E., Çalışkan S.

REVISTA BRASILEIRA DE ANESTESIOLOGIA, vol.69, no.4, pp.403-412, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.1016/j.bjan.2019.03.006
  • Journal Name: REVISTA BRASILEIRA DE ANESTESIOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.403-412
  • Keywords: Cyclooxygenase inhibitor, Intrathecal injection, (S)-(+)-Ketoprofen, Neurotoxicity, Inflammation, POSTOPERATIVE PAIN, DICLOFENAC SODIUM, KETOROLAC, DRUGS, CYCLOOXYGENASE-1, LIDOCAINE, TOXICITY, FENTANYL, SAFETY, ADULT
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Background and objectives: Intrathecal administration of non-steroidal anti-inflammatory drugs is more efficacious for post-operative pain management. Cyclooxygenase inhibiting nonsteroidal anti-inflammatory drugs like (S)-(+)-Ketoprofen, may be effective at lower intrathecal doses than parenteral ones. Preclinical safety regarding possible neurotoxicity associated with the intrathecal (S)-(+)-Ketoprofen was not evaluated. Here we analysed the neurotoxicity of intrathecally administered (S)-(+)-Ketoprofen in rats.