Screening and evaluation of antioxidant activity of some amido-carbonyl oxime derivatives and their radical scavenging activities

Özen T., Taş M.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, no.5, pp.1141-1147, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2009
  • Doi Number: 10.1080/14756360802669981
  • Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1141-1147
  • Keywords: Amido-carbonyl oxime, Antioxidant activity, Oxime, Radical scavenging activity
  • Ondokuz Mayıs University Affiliated: No

Abstract

The antioxidant activity of some amido-carbonyl oximes containing a C=O and -NH-R adjacent to the oxime group, [Phenyl-C(=O)-C(=N-OH)-N(-H)-Phenyl(-R)] where R=H, 4-chloro, 4-methyl, 4-methoxy, 3,4-dichloro, 3,4-dimethyl, 3-chloro-4-dimethyl, 3-chloro-4-methoxy, naphthyl and an amido-carbonyl dioxime were investigated in vitro by ferric thiocyanate, total reducing power by potassium ferricyanide reduction, 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging, ferrous ions chelating, superoxide anion radical scavenging and hydrogen peroxide scavenging activity assays. The results indicated that the amido-carbonyl oximes have powerful antioxidant capacity.