BLOCKADE OF P-SELECTIN REDUCES NEUTROPHIL INFILTRATION INTO THE ISCHEMIA-REPERFUSION INDUCED MURINE TESTIS

Celebi M., Paul A.

ACTA VETERINARIA-BEOGRAD, vol.59, no.5-6, pp.449-455, 2009 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 5-6
  • Publication Date: 2009
  • Doi Number: 10.2298/avb0906449c
  • Journal Name: ACTA VETERINARIA-BEOGRAD
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.449-455
  • Keywords: antibodies, neutrophils, P-selectin, testis, torsion, CELL-SPECIFIC APOPTOSIS, EXPRESSION, BLOCKING, PROTECTS, INJURY
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Germ cell apoptosis after ischemia-reperfusion (IR) of the testis is dependent on neutrophil recruitment to the testis. Intravascular adhesion molecules like the P- and E- selectins play an important role in this recruitment. The purpose of this study was to inhibit neutrophil recruitment to the IR- induced testis by using a function-blocking monoclonal anti-mouse P-selectin antibody.