BLOCKADE OF P-SELECTIN REDUCES NEUTROPHIL INFILTRATION INTO THE ISCHEMIA-REPERFUSION INDUCED MURINE TESTIS

Celebi M., Paul A.

ACTA VETERINARIA-BEOGRAD, cilt.59, sa.5-6, ss.449-455, 2009 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 5-6
  • Basım Tarihi: 2009
  • Doi Numarası: 10.2298/avb0906449c
  • Dergi Adı: ACTA VETERINARIA-BEOGRAD
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.449-455
  • Anahtar Kelimeler: antibodies, neutrophils, P-selectin, testis, torsion, CELL-SPECIFIC APOPTOSIS, EXPRESSION, BLOCKING, PROTECTS, INJURY
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Germ cell apoptosis after ischemia-reperfusion (IR) of the testis is dependent on neutrophil recruitment to the testis. Intravascular adhesion molecules like the P- and E- selectins play an important role in this recruitment. The purpose of this study was to inhibit neutrophil recruitment to the IR- induced testis by using a function-blocking monoclonal anti-mouse P-selectin antibody.