The aim of this study is to examine the serial mediating roles of shyness, interaction anxiety, interaction anxiety, and true self-perception on the internet in the relationship between self-esteem and phubbing. A total of 646 people, including 391 women (60.5%) and 255 men (39.5%), participated in the study. The ages of the study participants ranged from 18 to 45 (mean= 28.11, SD= 8.25) data from the research were collected with the Self-Esteem Scale, Interaction Anxiety Scale, General Phubbing Scale, Revised Buss and Check Shyness Scale, UCLA Loneliness Scale- Short Form, and True Me on the Net Scale. The descriptive statistics of the data collected in the study were calculated and correlation analysis was performed to determine the relationships between the variables. Mediation analyses in the research were made by using Hayes process macro-Model 6. As a result of serial mediation analysis, it is seen that the total effect of self-esteem on phubbing is significant. In addition, it was found that shyness, loneliness, interaction anxiety, and true self-perception on the internet had a significant direct effect on phubbing. Finally, shyness, interaction anxiety, loneliness, and true self-perception on the internet were found to have significant multiple serial mediating roles in the relationship between self-esteem and phubbing.