The aim of the present study was to investigate quality of life (QL) as a predictor of smartphone addiction risk among Turkish adolescents. In line with this purpose, a total of 352 high school students (153 males and 199 females) completed the Pediatric Quality of Life Inventory and a Smartphone Addiction Scale during the 2015-2016 academic year. Simple and multiple linear regression analysis was used to examine the association between QL and smartphone addiction risk. The results of this study suggested that the dimensions of physical and psychosocial health, as well as overall QL, negatively correlated with smartphone addiction in Turkish high school students. Therefore, school counselors should help their clients to improve their QL in order to effectively prevent smartphone addiction risk among high school students.