Cu(ii) salen and 1,2,4-triazole complexes from thiosemicarbazone: synthesis, physicochemical and structural properties and cytotoxic activities

AVCU ALTIPARMAK E., Erdemir G., Özdemir N., Kuruca S. E., BAL DEMİRCİ T.

NEW JOURNAL OF CHEMISTRY, vol.44, no.14, pp.5333-5342, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 14
  • Publication Date: 2020
  • Doi Number: 10.1039/c9nj04455h
  • Journal Name: NEW JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Biotechnology Research Abstracts, Chimica, EMBASE, DIALNET
  • Page Numbers: pp.5333-5342
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

A triazole complex of copper(ii) containing ethylenediamine as a coligand was synthesized using salicylaldehydethiosemicarbazone in the presence of CuCl2. Also, a dinuclear copper(ii) complex was synthesized using the same reagents; however, the order of their addition was different. The structures of these two complexes were characterized via elemental analysis, IR, H-1-NMR, and UV-Vis spectroscopy and mass spectrometry (MS). Furthermore, the molecular structures of complexes I and II were determined via single-crystal X-ray structure analysis. The copper(ii) ion has a distorted square-pyramidal geometry in complex I and a distorted square-planar geometry in complex II. Their fragmentation products were investigated in detail by ESI-MS. Finally, the cytotoxic effects of both complexes were evaluated in MDA-MB-231, MCF-7 and 3T3 fibroblast cell lines via the MTT assay and flow cytometry.