Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, cilt.11, sa.1, ss.164-169, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11 Sayı: 1
- Basım Tarihi: 2015
- Doi Numarası: 10.4103/0973-1482.140809
- Dergi Adı: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.164-169
- Anahtar Kelimeler: Arginase, carbamoyl phosphate synthetase 1, hepatotoxicity, infliximab, methotrexate, TUMOR-NECROSIS-FACTOR, NITRIC-OXIDE, CELL-GROWTH, INDUCED HEPATOTOXICITY, APOPTOSIS, THERAPY, CANCER
- Ondokuz Mayıs Üniversitesi Adresli: Hayır
Özet
Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor necrosis factor-alpha (TNF-alpha) has a protective effect against mtx-induced hepatotoxicity.