Research Information System
Turk Anesteziyoloji ve Reanimasyon, vol.26, no.3, pp.116-122, 1998 (Scopus)
The purpose of the present study was to produce a state of inhibition in the respiratory centers by adenozine administration (ICV) and to examine the respiratory response to hypoxia. The experiments were carried out in 12 cats under tiopenthone anaesthesia. Studies involved six peripheral chemodenervated vagotomized and six control cats with intact vagi and carotid bodies. For ICV injections of adenozine in each animal, canula was placed in left lateral cerebral ventricle by stereotaxic method. The control and peripheral chemodenervated vagotomized animals were allowed to breath air, hypoxic (8% O2-N2) gas mixture before and after ICV adenozine administration. When control animals were allowed to breath hypoxic gas mixture before adenozine administration, V(T), V(E) and f were found to increase significantly (p<0.05, p<0.01, p<0.01). Following adenozine administration, V(T) and V(E) were found to decrease significantly in control animals (p<0.01, p<0.01). Under this circumstances when animals were exposed to hypoxia and adenozine was administered V(T) and V(E) increased significantly (p<0.001, p<0.01). No decrease in magnitude of respiratory response to hypoxia was observed in control animals after adenozine administration. When chemodenervated vagotomized animals were allowed to breath the hypoxic gas mixture before adenozine administration V(T) and V(E) decreased significantly (p<0.05, p<0.05). When adenozine was administered to the chemodenervated vagotomized animals the V(T) and V(E) decreased during air breathing (p<0.01, p<0.05). On breathing of hypoxic gas mixture following adenozine administration further diminution in V(T) and V(E) were observed (p<0.05, p<0.05). The respiratory response of the chemodenervated vagotomized animals to hypoxia after adenozine administration was found to be as same as that before adenozine administration. The results of this study show that adenozine acts as a central depressant of respiration during air breathing. However respiratory centers the activity of which is depressed by adenozine in normoxia can still responded to hypoxia.