Synthesis, crystal structure, spectroscopy, thermal properties and carbonic anhydrase activities of new metal(II) complexes with mefenamic acid and picoline derivatives

Dilek E., Çağlar S., Dogancay N., Çağlar B., Sahin O., Tabak A.

JOURNAL OF COORDINATION CHEMISTRY, sa.16, ss.2833-2852, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/00958972.2017.1366996
  • Dergi Adı: JOURNAL OF COORDINATION CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2833-2852
  • Anahtar Kelimeler: carbonic anhydrases, Mefenamic acid, metal complex, picoline
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The mononuclear six metal(II) complexes ([Co(mef)(2)(3-pic)(2)(CH3OH)(2)] (1), [Ni(mef)(2)(3-pic)(2)(CH3OH)(2)] (2), [Cu(mef)(2)(3-pic)(2)] (3), [Co(mef)(2)(4-pic)(2)] (4), [Ni(mef)(2)(4-pic)(2)] (5), and [Cu(mef)(2)(4-pic)(2)] (6) with mefenamic acid and picoline ligands were synthesized, characterized, and their carbonic anhydrase inhibitory activities were evaluated. The six complexes were characterized by elemental analysis, FT-IR spectroscopy, and thermal analyses. The crystal structures of 1, 3, and 6 were determined by X-ray crystallography. The complexes have octahedral geometry. In 1, the mefenamato ligand behaved as monodentate whereas in 3 and 6, the mefenamato ligand acted as a bidentate ligand. Complexes 3 and 6 consist of the mefenamate and 4-picoline ligands. In 1, unlike the other complexes, methanol acted as a ligand and was involved in the coordination. Carbonic anhydrase I and II isoenzymes were purified from human erythrocytes. The in vitro effects of mefenamic acid, 3-picoline, 4-picoline, and the six metal(II) complexes on these isoenzymes were evaluated. [GRAPHICS]