Occurrence of metallothionein immunostaining in feline mammary epithelial neoplasms

Erginsoy S., Sozmen M., Caldin M., Furlanello T.

REVUE DE MEDECINE VETERINAIRE, vol.156, no.11, pp.537-540, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 156 Issue: 11
  • Publication Date: 2005
  • Journal Name: REVUE DE MEDECINE VETERINAIRE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.537-540
  • Ondokuz Mayıs University Affiliated: No

Abstract

Metallothioneins (MTs), a set of ubiquitous low-molecular-weight proteins. were detected immunohistochemically using a monoclonal antibody (E9) against a conserved epitope of I and 11 isoforms in a serie of 19 feline mammary tumours. In a semi-quantitative analysis, unequivocal MT expression in the turnout cells was observed in 2/3 cases of benign and 8/16 malignant mammary neoplasms. The mean immunoreactive score was higher in benign mammary neoplasms compared to malign turnouts. But. MT was differently expressed according to the type of malignant tumours. The MT expression was demonstrated in 80% of feline ductular mammary carcinomas. whereas its occurrence in mammary gland adenocarcinomas was only 36%. It is concluded that immunohistochemically demonstrated MT expression is associated with feline benign mammary turnouts and ductular carcinomas.